Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human,Xenobiotica

当前位置： X-MOL 学术 › Xenobiotica › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human
Xenobiotica ( IF 1.8 ) Pub Date : 2024-01-15 , DOI: 10.1080/00498254.2024.2303586
Laurent Salphati ₁ , Jodie Pang ₁ , Bruno Alicke ₁ , Emile G. Plise ₁ , Jonathan Cheong ₁ , Allan Jaochico ₁ , Alan G. Olivero ₁ , Deepak Sampath ₁ , Susan Wong ₁ , Xiaolin Zhang ₁

Affiliation

Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults. Available treatments have not markedly improved patient survival in the last twenty years. However, genomic investig...

中文翻译：