Hypertension caused by vascular Behcet’s disease (BD) is an important prognostic factor of paediatric BD. However, much less is known about its clinical features. The objective of this study was to investigate the clinical characteristics of paediatric vascular BD complicated by hypertension. A retrospective study was carried out in paediatric BD patients complicated by hypertension treated in the Children’s Hospital Capital Institute of Paediatrics from Jan 2009 to Dec 2022. Of 65 BD patients, 6 (9.2%) were complicated by hypertension, 5 patients were female, and the median ages of onset and diagnosis were 9.8 years and 11.3 years, respectively. Three patients were found to have cardiac involvement and hypertensive retinopathy secondary to hypertension. Five of the 6 patients with hypertension had right renal artery involvement, and all of them were treated with glucocorticoids and immunosuppressants. Four patients were treated with biological agents. One patient with severe renal artery stenosis underwent unsuccessful vascular interventional therapy. After 3–6 years of follow-up, five patients were found to have renal atrophy, and one patient was at stable condition. Hypertension in paediatric BD is mainly caused by renal artery involvement. Early recognition and treatment of vascular involvement in BD is important to prevent poor prognosis.

中文翻译：

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高血压是小儿白塞病肾动脉病变继发的突出表现

血管性白塞病（BD）引起的高血压是儿童BD的重要预后因素。然而，人们对其临床特征知之甚少。本研究的目的是探讨小儿血管性BD并发高血压的临床特征。对2009年1月至2022年12月首都儿科研究所儿童医院收治的BD并发高血压患儿进行回顾性研究。65例BD患者中，6例（9.2%）并发高血压，其中女性5例，发病和诊断的中位年龄分别为 9.8 岁和 11.3 岁。3 名患者被发现有心脏受累和继发于高血压的高血压性视网膜病变。6例高血压患者中5例有右肾动脉受累，均接受糖皮质激素和免疫抑制剂治疗。四名患者接受了生物制剂治疗。1例肾动脉严重狭窄患者接受血管介入治疗失败。经过3-6年的随访，5名患者发现肾萎缩，1名患者病情稳定。小儿 BD 的高血压主要是由肾动脉受累引起的。BD 血管受累的早期识别和治疗对于预防不良预后非常重要。