Background Hyperandrogenism is among the most common endocrine disorders in women. Clinically, it manifests as hirsutism, acne, and alopecia. A healthy lifestyle, including nutritious dietary patterns and physical activity, may influence the clinical manifestation of the disease. This study determined the effect of a low-glycemic index anti-inflammatory diet on testosterone levels and sex hormone-binding globulin (SHBG) and clinical symptoms in hyperandrogenic women at their reproductive age.

Methods The study included 44 overweight and obese women diagnosed with hyperandrogenism. The anthropometrics (weight, height, body mass index, waist circumference, hip circumference), physical activity, and dietary habits were assessed using valid questionnaires, scales, stadiometer, and tape meter. The significant p-value was <0.001. Serum testosterone and SHBG levels were measured using automated immunoassay instruments.

Results The intervention based on a low-glycemic index diet with anti-inflammatory elements and slight energy deficit decreased total testosterone levels (p<0.003), increased SHBG levels (p<0.001), and decreased the free androgen index (FAI; p<0.001). Post-intervention, overall well-being was much higher than in the pre-intervention period (p<0.001), and stress was diminished (p<0.001). Western nutritional patterns positively correlate with clinical hyperandrogenism progression, whereas several factors of the low-glycemic index diet with anti-inflammatory elements and slight energy deficit positively associate with reduced clinical hyperandrogenism symptoms.

Conclusions In overweight and obese women, proper selection of diet, introduction of moderate physical activity, and reduction in weight, stress factors, and alcohol consumption translate into several positive effects, including reduced FAI and symptoms such as acne, hirsutism, menstrual disorders, and infertility.

背景高雄激素血症是女性最常见的内分泌疾病之一。临床上表现为多毛、痤疮、脱发等。健康的生活方式，包括营养饮食模式和身体活动，可能会影响疾病的临床表现。这项研究确定了低血糖指数抗炎饮食对育龄期高雄激素女性的睾酮水平和性激素结合球蛋白（SHBG）以及临床症状的影响。

方法该研究纳入了 44 名被诊断患有雄激素过多症的超重和肥胖女性。使用有效的问卷、体重秤、测距仪和卷尺对人体测量数据（体重、身高、体重指数、腰围、臀围）、体力活动和饮食习惯进行评估。显着性 p 值<0.001。使用自动免疫测定仪器测量血清睾酮和性激素结合球蛋白（SHBG）水平。

结果基于低血糖指数饮食、抗炎成分和轻微能量不足的干预降低了总睾酮水平 (p<0.003)，增加了性激素结合球蛋白 (SHBG) 水平 (p<0.001)，并降低了游离雄激素指数 (FAI；p< 0.001）。干预后，整体幸福感远高于干预前 (p<0.001)，压力也有所减轻 (p<0.001)。西方营养模式与临床高雄激素血症的进展呈正相关，而含有抗炎成分和轻微能量缺乏的低血糖指数饮食的几个因素与临床高雄激素血症症状的减轻呈正相关。

结论对于超重和肥胖的女性，适当选择饮食、进行适度的体力活动以及减轻体重、压力因素和饮酒可产生多种积极效果，包括减少 FAI 以及痤疮、多毛症、月经失调和月经失调等症状。不孕症。