Photothermal therapy (PTT) usually requires stable and biocompatible photothermal agents, and more importantly, the ability to initiate photothermal effects inside the tumor under excitation of a near-infrared light source. Here, porphyrin-based covalent organic framework nanoparticles (COF-OH NPs) were prepared as a platform to successively load with indocyanine green (ICG). Compared to free ICG, the as-prepared composites (denoted as ICG@COF NPs) exhibited better stability and a higher photothermal conversion efficiency (56.7%) under 808 nm laser irradiation. In vitro experiments showed that ICG@COF NPs had good biocompatibility and high photothermal effects, which could effectively eradicate tumor cells when exposed to laser irradiation. Moreover, the remarkable ability to ablate tumors was further verified in vivo with 4T1 tumor-bearing mice as the model. After 10 days of treatment with ICG@COF NPs and laser irradiation, the tumors in mice were almost completely regressed, and the biochemical parameters of mice did not exhibit any significant abnormalities, indicating the significant therapeutic effect and high safety of the composites. Therefore, the development of ICG@COF NPs opens a new avenue for photothermal agents and expands the utilization of covalent organic frameworks in the biomedical area.

中文翻译：

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用于光热癌症治疗的吲哚青绿负载卟啉共价有机框架

光热疗法（PTT）通常需要稳定且生物相容的光热剂，更重要的是，需要在近红外光源的激发下在肿瘤内部启动光热效应的能力。在这里，制备了基于卟啉的共价有机框架纳米颗粒（COF-OH NP）作为平台，连续负载吲哚菁绿（ICG）。与游离ICG相比，所制备的复合材料（表示为ICG@COF NPs）在808 nm激光照射下表现出更好的稳定性和更高的光热转换效率（56.7％）。体外实验表明ICG@COF NPs具有良好的生物相容性和较高的光热效应，在激光照射下可以有效消灭肿瘤细胞。此外，以4T1荷瘤小鼠为模型，在体内进一步验证了其卓越的消融肿瘤能力。经过10天的ICG@COF NPs和激光照射治疗后，小鼠体内的肿瘤几乎完全消退，并且小鼠的生化参数没有出现任何明显的异常，表明该复合材料具有显着的治疗效果和较高的安全性。因此，ICG@COF NPs的开发为光热剂开辟了一条新途径，并扩大了共价有机框架在生物医学领域的应用。