Abstract

The study “A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease” by Milekovic et al. introduces a novel neuroprosthesis for treating locomotor deficits in late-stage Parkinson’s disease (PD). This approach employs an epidural spinal array targeting dorsal roots and electromyography to create a spatiotemporal map of muscle activation, aiming to restore natural gait patterns. Significant improvements in gait freezing and balance were observed in both non-human primate models and a human patient, resulting in improved mobility and quality of life. This innovative method, integrating real-time feedback and non-invasive motor intention decoding, marks a significant advancement in PD treatment.

中文翻译：

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冷冻步态治疗帕金森病又向前迈出了一步

摘要

Milekovic 等人的研究“用于治疗帕金森病引起的运动缺陷的脊髓神经假体”。推出了一种新型神经假体，用于治疗晚期帕金森病 (PD) 的运动缺陷。该方法采用针对背根的硬膜外脊柱阵列和肌电图来创建肌肉激活的时空图，旨在恢复自然步态模式。在非人类灵长类动物模型和人类患者中观察到步态冻结和平衡的显着改善，从而改善了活动能力和生活质量。这种创新方法结合了实时反馈和非侵入性运动意图解码，标志着帕金森病治疗的重大进步。