Abstract

The aim of this review is to examine the intersection of Parkinson’s disease (PD) with nutrition, to identify best nutritional practices based on current evidence, and to identify gaps in the evidence and suggest future directions. Epidemiological work has linked various dietary patterns and food groups to changes in PD risk; however, fewer studies have evaluated the role of various diets, dietary components, and supplements in the management of established PD. There is substantial interest in exploring the role of diet-related interventions in both symptomatic management and potential disease modification. In this paper, we evaluate the utility of several dietary patterns, including the Mediterranean (MeDi), Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND), Alternative Healthy Eating Index (AHEI), vegan/vegetarian, and ketogenic diet in persons with PD. Additionally, we provide an overview of the evidence relating several individual food groups and nutritional supplements to PD risk, symptoms and progression.

中文翻译：

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饮食在帕金森病中的作用

摘要

本综述的目的是研究帕金森病 (PD) 与营养的交叉点，根据当前证据确定最佳营养实践，并找出证据中的差距并提出未来的方向。流行病学工作已将各种饮食模式和食物类别与帕金森病风险的变化联系起来；然而，很少有研究评估各种饮食、饮食成分和补充剂在治疗帕金森病中的作用。人们对探索饮食相关干预措施在症状管理和潜在疾病改变中的作用有着浓厚的兴趣。在本文中，我们评估了几种饮食模式的效用，包括地中海饮食 (MeDi)、地中海 DASH 神经退行性延迟干预 (MIND)、替代健康饮食指数 (AHEI)、纯素食/素食和生酮饮食对帕金森病患者的效用。此外，我们还概述了几种单独的食物组和营养补充剂与帕金森病风险、症状和进展相关的证据。