In a remarkable recent study, Miao et al. reveal that gasdermin D N-terminal (GSDMD-NT) instigates mitochondrial damage in pyroptosis by forming pores in inner and outer mitochondrial membranes (OMMs). The authors highlight the key role of mitochondrial cardiolipin in the action of GSDMD-NT, and significantly advance our understanding of this inflammatory cell death mechanism.

中文翻译：

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Gasdermin D 触发心磷脂驱动的线粒体损伤和细胞焦亡

在最近一项引人注目的研究中，Miao等人。研究表明，gasdermin D N 末端 (GSDMD-NT) 通过在线粒体内外膜 (OMM) 上形成孔，从而在细胞焦亡中引发线粒体损伤。作者强调了线粒体心磷脂在 GSDMD-NT 作用中的关键作用，并显着增进了我们对这种炎症细胞死亡机制的理解。