Abstract

p53 is a transcription factor, which is encoded by the TP53 gene in human. p53 regulates the cell cycle and functions as a tumour suppressor, thus, involved in preventing cancer. In vivo, analysis of p53 mechanisms in whole animal models are critical, alternatively Drosophila can be selected. Our present study worked on comparative and interactome profiling of p53 protein using PyMol and Haddock 2.4. The structural similarity resulted that p53 of Drosophila (Dmp53) is almost alike to that of human p53 (Hp53) protein. Hp53 interacting proteins were systematically docked and analyzed with Hp53 and Dmp53 both. Furthermore the associated complexes are analysed through Discovery Studio. The interactome study revealed better homologous interaction like human p53. Drosophila p53 exhibits characteristics that makes it a promising model for cancer research, bearing resemblance to human p53.

中文翻译：

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对结构同源的果蝇 p53 与人类 p53 进行计算机评估，以确定未来治疗研究的功能差异

摘要

p53是一种转录因子，由人类TP53基因编码。p53 调节细胞周期并发挥肿瘤抑制因子的作用，从而参与预防癌症。在体内，分析整个动物模型中的 p53 机制至关重要，或者可以选择果蝇。我们目前的研究使用 PyMol 和 Haddock 2.4 对 p53 蛋白进行比较和相互作用组分析。结构相似性导致果蝇的p53 （Dmp53）与人类p53（Hp53）蛋白几乎相似。Hp53 相互作用蛋白与 Hp53 和 Dmp53 进行系统对接和分析。此外，相关复合物通过 Discovery Studio 进行分析。相互作用组研究揭示了与人类 p53 类似的更好的同源相互作用。果蝇p53 所表现出的特性使其成为癌症研究的有前景的模型，与人类 p53 相似。