Two reports by and , respectively, show that, through installing chiral centers at the backbone of the artificial nucleic acid, peptide nucleic acid (PNA), enhanced miRNA targeting and genome modification can be achieved, with important implications in fighting cancers and β-thalassemia.

中文翻译：

---

预扭曲以改善基因组修饰和 miRNA 靶向

和 的两份报告分别表明，通过在人工核酸、肽核酸（PNA）的主链上安装手性中心，可以实现增强的 miRNA 靶向和基因组修饰，这对对抗癌症和β-地中海贫血具有重要意义。