Endoplasmic reticulum (ER) stress plays a key role in the pathogenesis of several organ damages. Studies show that excessive ER stress (ERS) can destroy cellular homeostasis, causing cell damage and physiological dysfunction in various organs. In recent years, Sirtuin1 (SIRT1) has become a research hotspot on ERS. Increasing evidence suggests that SIRT1 plays a positive role in various ERS-induced organ damage via multiple mechanisms, including inhibiting cellular apoptosis and promoting autophagy. SIRT1 can also alleviate liver, heart, lung, kidney, and intestinal damage by inhibiting ERS. We discuss the possible mechanism of SIRT1, explore potential therapeutic targets of diseases, and provide a theoretical basis for treating ERS-related diseases.

内质网（ER）应激在多种器官损伤的发病机制中起着关键作用。研究表明，过度的内质网应激（ERS）会破坏细胞稳态，导致细胞损伤和各器官的生理功能障碍。近年来，Sirtuin1（SIRT1）已成为ERS的研究热点。越来越多的证据表明，SIRT1 通过多种机制在 ERS ​​诱导的各种器官损伤中发挥积极作用，包括抑制细胞凋亡和促进自噬。SIRT1还可以通过抑制ERS来减轻肝、心、肺、肾和肠道损伤。我们探讨了SIRT1的可能机制，探索疾病的潜在治疗靶点，为治疗ERS相关疾病提供理论基础。