Introduction

This study will explore the effectiveness of autologous platelet-rich plasma in the treatment of diabetic foot disease compared to conventional treatments, based on the ulcer healing rate.

Methods

The electronic databases of PubMed, EMBASE, and WOS internet were searched. Evaluated outcome rate of complete ulcer healing. Statistical analysis was performed with RevMan 5.0 software and SPSS 25.0.

Results

Eleven RCTs with 828 patients were included in this study. The meta-analysis showed a higher complete ulcer healing rate (OR = 3.69, 95 % CI 2.62 to 5.20, P < 0.01, I² = 0 %) in growth factors based in autologous platelech-rich plasma (aPRP) group compared with control. Mixed evidence was seen for publication bias, but analyses by using the trim-and-fill method did not appreciably alter results.

Conclusion

Autologous platelet-rich plasma can improve the complete healing rate of the ulcer compared to current conventional treatments in diabetic foot ulcer patients.

中文翻译：

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自体富血小板血浆（APRP）治疗糖尿病足病：荟萃分析

介绍

本研究将根据溃疡愈合率，探讨自体富血小板血浆与传统治疗相比在治疗糖尿病足病方面的有效性。

方法

检索了PubMed、EMBASE和WOS internet的电子数据库。评估溃疡完全愈合的结果率。采用RevMan 5.0软件和SPSS 25.0进行统计分析。

结果

本研究纳入了 11 项随机对照试验，涉及 828 名患者。荟萃分析显示， 与对照组相比，基于自体富含血小板血浆 (aPRP) 的生长因子组的溃疡完全愈合率更高（OR = 3.69，95 % CI 2.62 至 5.20， P  < 0.01，I ² = 0 %） 。发表偏倚的证据不一，但使用修剪填充方法进行的分析并没有明显改变结果。

结论

与目前糖尿病足溃疡患者的常规治疗相比，自体富血小板血浆可以提高溃疡的完全愈合率。