The solubility of drugs is an important physicochemical data for its development and design. In this work, the solubility of 2-mercaptobenzimidazole (2-MBI) in eleven mono-solvent solvents (2-propoxyethanol, isopropyl acetate, butyl acetate, 2-methoxyethanol, 2-butanol, ethyl formate, 2-ethoxyethanol, isobutanol, 4-methyl-2-pentanone, 2-butoxyethanol and ethylene glycol) and three binary solvents (2-methoxyethanol + ethyl formate, 2-methoxyethanol + isopropyl acetate, 2-ethoxyethanol+ ethyl formate) was measured by a gravimetric analysis method at the temperatures from 283.15 to 323.15 K. The solubility of 2-MBI in the studied solvents increased with the increasing temperature. The measured solubility data of 2-MBI was described mathematically and back-calculated by CNIBS/R-K model, Margules model, UNIQUAC model, Jouyban-Acree-van't Hoff model and NRTL model. Hansen solubility parameters was calculated to assess the qualitative trend of 2-MBI in all selected mono and binary mixed solvents, analysis results indicating that the solubilization behavior of 2-MBI was intricate and can not only be assessed by one factor. In this study, the apparent thermodynamic parameters including ∆, ∆, ∆, and were investigated, positive values of ∆ indicating that the corresponding dissolution process of 2-MBI in all selected solvents was endothermic. In conclusion, these experimental and thermodynamic analysis can enrich the database and give support for design and optimize the crystallization process of 2-MBI.

中文翻译：

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不同温度下2-巯基苯并咪唑在11种单溶剂和3种二元溶剂中的固液平衡溶解度、建模、汉森溶解度参数和热力学分析

药物的溶解度是其开发和设计的重要理化数据。在这项工作中，2-巯基苯并咪唑（2-MBI）在11种单溶剂溶剂（2-丙氧基乙醇、乙酸异丙酯、乙酸丁酯、2-甲氧基乙醇、2-丁醇、甲酸乙酯、2-乙氧基乙醇、异丁醇、4 -甲基-2-戊酮、2-丁氧基乙醇和乙二醇）和三种二元溶剂（2-甲氧基乙醇+甲酸乙酯、2-甲氧基乙醇+乙酸异丙酯、2-乙氧基乙醇+甲酸乙酯）在温度为283.15 至 323.15 K。2-MBI 在所研究溶剂中的溶解度随着温度的升高而增加。通过CNIBS/RK模型、Margules模型、UNIQUAC模型、Jouyban-Acree-van't Hoff模型和NRTL模型对2-MBI的测量溶解度数据进行数学描述和反算。计算汉森溶解度参数来评估 2-MBI 在所有选定的一元和二元混合溶剂中的定性趋势，分析结果表明 2-MBI 的增溶行为是复杂的，不能仅通过一个因素来评估。本研究对表观热力学参数包括Δ、Δ、Δ进行了研究，Δ的正值表明2-MBI在所有选定溶剂中的相应溶解过程是吸热的。总之，这些实验和热力学分析可以丰富数据库，为2-MBI结晶过程的设计和优化提供支持。