Abstract

Radical copolymerization of coumarin with N-vinylamides (N‑vinylpyrrolidone, N-methyl-N-vinylacetamide, N-vinylformamide) has been used to prepare copolymers of various composition with variable molecular weights. Subsequent reactions in their polymer chains affords water-soluble copolymers of salts of hydroxycinnamic acid and its hydrazides. The synthesized copolymers of hydroxycinnamic acid salts and hydrazides with N-vinylamides have low cytotoxicity and demonstrate the pronounced antiviral activity against human respiratory syncytial virus (strain A2).

中文翻译：

---

羟基肉桂酸与N-乙烯基酰胺共聚物的合成及抗病毒活性

摘要

香豆素与N-乙烯基酰胺（N-乙烯基吡咯烷酮、N-甲基-N-乙烯基乙酰胺、N-乙烯基甲酰胺）的自由基共聚已被用来制备具有不同分子量的各种组成的共聚物。随后在其聚合物链中发生反应，得到羟基肉桂酸盐及其酰肼的水溶性共聚物。合成的羟基肉桂酸盐和酰肼与N-乙烯基酰胺的共聚物具有低细胞毒性，并且对人呼吸道合胞病毒（A2株）具有显着的抗病毒活性。