Abstract

Purpose of Review

Trigeminal postherpetic neuralgia (TG-PHN) is a neuropathic pain condition complicating herpes zoster (HZ) attributed to the trigeminal nerve. It poses significant challenges due to its persistent and debilitating nature. This review explores the clinical characteristics of TG-PHN, analyzes its pathophysiological underpinnings, and addresses existent and potential therapies.

Recent Findings

TG-PHN is one of the most common and complex PHN locations. It has distinguishing clinical and pathophysiological characteristics, starting with viral triggered injuries to the trigeminal ganglion (TG) and peripheral tissue and involving the ascending and descending brain modulation pathways. Current therapies include vaccines, oral and topical medications, and interventional approaches, like nerve blocks and neurostimulation.

Summary

This review covers TG-PHN’s clinical and physiological components, treatment options, and potential future targets for improved management. By exploring the complexities of this condition, we aim to contribute to developing more effective and targeted therapies for patients suffering from trigeminal PHN.

中文翻译：

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三叉神经带状疱疹后神经痛：从病理生理学到治疗

摘要

审查目的

三叉神经带状疱疹后神经痛 (TG-PHN) 是一种由三叉神经引起的带状疱疹 (HZ) 并发的神经性疼痛。由于其持久性和使人衰弱的性质，它带来了重大挑战。本综述探讨了 TG-PHN 的临床特征，分析其病理生理学基础，并讨论现有和潜在的治疗方法。

最近的发现

TG-PHN 是最常见和最复杂的 PHN 位置之一。它具有独特的临床和病理生理学特征，首先是病毒触发三叉神经节（TG）和周围组织的损伤，并涉及大脑的上行和下行调节途径。目前的治疗方法包括疫苗、口服和外用药物以及神经阻滞和神经刺激等介入方法。

概括

本综述涵盖了 TG-PHN 的临床和生理组成部分、治疗方案以及改进管理的未来潜在目标。通过探索这种疾病的复杂性，我们的目标是为三叉神经 PHN 患者开发更有效、更有针对性的治疗方法。