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Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-01-23 , DOI: 10.1080/14756366.2024.2305852 Zhuoying Chen 1 , Quan Wang 1 , Yao Yao Yan 1 , Dalong Jin 1 , Yumeng Wang 1 , Xing Xing Zhang 2 , Xin Hua Liu 1
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-01-23 , DOI: 10.1080/14756366.2024.2305852 Zhuoying Chen 1 , Quan Wang 1 , Yao Yao Yan 1 , Dalong Jin 1 , Yumeng Wang 1 , Xing Xing Zhang 2 , Xin Hua Liu 1
Affiliation
It has been reported that CDK8 plays a key role in acute myeloid leukaemia. Here, a total of 40 compounds were rational designed and synthesised based on the previous SAR. Among them, compound 12 (...
中文翻译：
发现治疗急性髓系白血病的新型有效 CDK8 抑制剂
据报道，CDK8在急性髓性白血病中起关键作用。这里，在前期SAR的基础上，合理设计合成了总共40个化合物。其中，化合物12（...
更新日期：2024-01-23
中文翻译：
发现治疗急性髓系白血病的新型有效 CDK8 抑制剂
据报道，CDK8在急性髓性白血病中起关键作用。这里，在前期SAR的基础上，合理设计合成了总共40个化合物。其中，化合物12（...
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