Human T-cell leukemia virus type 1 (HTLV-1) can cause HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Current treatment options for HAM/TSP are limited. We present a woman with rapidly-progressive HAM/TSP with significant, sustained clinical improvement following initiation of mycophenolate mofetil (MMA). Peripheral blood mononuclear cells from the patient, her asymptomatic carrier husband and eight healthy controls were isolated. Frequencies of T-cell populations upon exposure to low and high MMA concentrations and differences in proliferation were analyzed using flow cytometry and a CSFE-proliferation assay. Characterization of T-cell function and proliferation showed higher levels of GranzymeB in HTLV-1+ donors. The improvement and stability of symptoms in this patient with HAM/TSP following MMA initiation requires further study as a potential treatment for HAM/TSP.

人类 T 细胞白血病病毒 1 型 (HTLV-1) 可引起 HTLV-1 相关脊髓病/热带痉挛性截瘫 (HAM/TSP)。目前HAM/TSP 的治疗选择有限。我们介绍了一位患有快速进展的 HAM/TSP 的女性，在开始服用吗替麦考酚酯 (MMA) 后，临床症状持续显着改善。分离了患者、她的无症状携带者丈夫和八名健康对照者的外周血单核细胞。使用流式细胞术和 CSFE 增殖测定分析暴露于低和高 MMA 浓度时的 T 细胞群频率以及增殖差异。 T 细胞功能和增殖特征显示 HTLV-1+ 供体中粒酶 B 水平较高。该 HAM/TSP 患者在开始 MMA 后症状的改善和稳定需要进一步研究，作为 HAM/TSP 的潜在治疗方法。