Various reviews and meta-analyses have shown the positive effects of mindfulness-based interventions (MBIs) on the mental health of cancer patients and survivors. Some studies have also investigated the impact of MBIs on physiological markers of health in oncology, but a systematic review has not been conducted in this field. The current paper aims to fill this gap in the literature. Following preferred reporting items for systematic reviews and meta-analyses 2020 guidelines, data were obtained from the databases of Pubmed, Scopus, Web of Science in May 2022. Twenty-five studies were included. Globally, 35 biomarkers were employed in these studies and were categorized 8 groups (cortisol; blood pressure (BP), heart rate, and respiratory rate; C-reactive protein; telomere length and telomerase activity (TA); genetic signature; cytokines and hormones; leucocyte activation; leucocyte count and cell subpopulation analysis). In seven of these categories of biomarkers, positive effects of MBIs were observed. The most promising results were obtained for cortisol, BP, TA and pro-inflammatory gene expression. However, the generally low number of studies per single biomarker limits the possibility to draw reliable conclusions. The present review presents a comprehensive state-of-the-art for MBIs in oncology on biomarkers, confirming MBIs' potential for improving physiological health in cancer patients and survivors besides those already shown in literature on psychological well-being.

中文翻译：

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基于正念的干预措施对癌症患者和幸存者生物标志物的影响：系统评价

各种综述和荟萃分析表明，基于正念的干预措施（MBI）对癌症患者和幸存者的心理健康具有积极影响。一些研究还调查了 MBI 对肿瘤学健康生理标志物的影响，但该领域尚未进行系统评价。当前的论文旨在填补文献中的这一空白。根据 2020 年系统评价和荟萃分析指南的首选报告项目，数据于 2022 年 5 月从 Pubmed、Scopus、Web of Science 数据库中获取。纳入了 25 项研究。在全球范围内，这些研究采用了 35 种生物标志物，分为 8 组（皮质醇；血压 (BP)、心率和呼吸频率；C 反应蛋白；端粒长度和端粒酶活性 (TA)；遗传特征；细胞因子和激素） ；白细胞活化；白细胞计数和细胞亚群分析）。在其中七类生物标志物中，观察到 MBI 的积极作用。最有希望的结果是皮质醇、BP、TA 和促炎基因表达。然而，每种生物标志物的研究数量普遍较少，限制了得出可靠结论的可能性。本综述介绍了 MBI 在肿瘤学中生物标志物的最新进展，证实了除了心理健康文献中已经显示的那些之外，MBI 还具有改善癌症患者和幸存者生理健康的潜力。