To investigate the association between autonomic dysfunction (AutD) and motor as well as non-motor symptoms (NMS) in patients with Parkinson's disease (PD). Fifty-three PD patients were divided into two groups based on the number of domains affected by AutD: a multi-domain AutD group (AutD-M) and a single-domain AutD group (AutD-S), as evaluated using the Scale for Outcomes in Parkinson's disease-Autonomic (SCOPA-AUT), which assesses autonomic symptoms, one of the NMS. A comprehensive comparison was conducted between the two groups, including clinical measures such as clinical scales, quantitative evaluations of motor function and exercise capacity. Spearman correlation analysis was employed to investigate the relationship between AutD severity and PD symptoms. Additionally, we performed multiple linear regression model analysis to determine whether associations between SCOPA-AUT scores and clinical assessments remained significant after adjusting for Hoehn and Yahr stage, sex, and age. PD patients in the AutD-M group exhibited significantly more severe NMS and motor symptoms compared to those in the AutD-S group. In correlation analysis, SCOPA-AUT scores showed significant correlations with multiple clinical symptoms, such as most of the NMS, 10-MWT and CPET parameters. Furthermore, regression analysis also revealed that more pronounced fatigue, anxiety, depressive symptoms, worse walking speed and impaired exercise capacity were associated with higher SCOPA-AUT scores. The presence of AutD is correlated with emotional disturbances, decreased exercise endurance, and impaired gait function in patients with PD. Early management of AutD may prove beneficial in alleviating some NMS and motor symptoms in PD.

研究帕金森病 (PD) 患者自主神经功能障碍 (AutD) 与运动和非运动症状 (NMS) 之间的关联。根据受 AutD 影响的域数量将 53 名 PD 患者分为两组：多域 AutD 组 (AutD-M) 和单域 AutD 组 (AutD-S)，使用量表进行评估帕金森病自主神经 (SCOPA-AUT) 的结果，评估自主神经症状，是 NMS 之一。对两组进行全面比较，包括临床量表、运动功能和运动能力的定量评价等临床指标。采用 Spearman 相关分析来研究 AutD 严重程度与 PD 症状之间的关系。此外，我们进行了多元线性回归模型分析，以确定在调整 Hoehn 和 Yahr 分期、性别和年龄后，SCOPA-AUT 评分与临床评估之间的关联是否仍然显着。与 AutD-S 组相比，AutD-M 组的 PD 患者表现出明显更严重的 NMS 和运动症状。在相关性分析中，SCOPA-AUT评分显示与多种临床症状显着相关，例如大部分NMS、10-MWT和CPET参数。此外，回归分析还显示，更明显的疲劳、焦虑、抑郁症状、较差的步行速度和运动能力受损与较高的 SCOPA-AUT 分数相关。AutD 的存在与 PD 患者的情绪障碍、运动耐力下降和步态功能受损相关。AutD 的早期治疗可能有助于缓解 PD 中的一些 NMS 和运动症状。