No study has shown the relationship between alanine-glyoxylate aminotransferase 2 (AGXT2) single nucleotide polymorphisms (SNPs) and depressive symptoms. The present case–control study examined this relationship in Japanese adults. Cases and control participants were selected from those who participated in the baseline survey of the Aidai Cohort Study, which is an ongoing cohort study. Cases comprised 280 participants with depressive symptoms based on a Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16. Control participants comprised 2034 participants without depressive symptoms based on the CES-D who had not been diagnosed by a physician as having depression or who had not been currently taking medication for depression. Adjustment was made for age, sex, smoking status, alcohol consumption, leisure time physical activity, education, body mass index, hypertension, dyslipidemia, and diabetes mellitus. Compared with the GG genotype of rs180749, both the GA and AA genotypes were significantly positively associated with the risk of depressive symptoms assessed by the CES-D: the adjusted odds ratios for the GA and AA genotypes were 2.83 (95% confidence interval [CI] 1.23–8.24) and 3.10 (95% CI 1.37–8.92), respectively. The TGC haplotype of rs37370, rs180749, and rs16899974 was significantly inversely related to depressive symptoms (crude OR 0.67; 95% CI 0.49–0.90), whereas the TAC haplotype was significantly positively associated with depressive symptoms (crude OR 1.24; 95% CI 1.01–1.52). This is the first study to show significant associations between AGXT2 SNP rs180749, the TGC haplotype, and the TAC haplotype and depressive symptoms.

尚无研究表明丙氨酸乙醛酸转氨酶 2 ( AGXT2 ) 单核苷酸多态性 (SNP) 与抑郁症状之间的关系。本病例对照研究在日本成年人中检验了这种关系。病例和对照参与者选自参与 Aidai 队列研究基线调查的参与者，该研究是一项正在进行的队列研究。病例包括 280 名根据流行病学研究中心抑郁量表 (CES-D) 评分≥ 16 出现抑郁症状的参与者。对照参与者包括 2034 名根据 CES-D 没有抑郁症状但未被医生诊断为患有抑郁症的参与者或目前尚未服用抑郁症药物的人。对年龄、性别、吸烟状况、饮酒量、休闲时间体力活动、教育程度、体重指数、高血压、血脂异常和糖尿病进行了调整。与rs180749的GG基因型相比，GA和AA基因型均与CES-D评估的抑郁症状风险显着正相关：GA和AA基因型的调整优势比为2.83（95%置信区间[CI] ] 1.23–8.24) 和 3.10 (95% CI 1.37–8.92)。rs37370、rs180749 和 rs16899974 的 TGC 单倍型与抑郁症状显着负相关（粗略 OR 0.67；95% CI 0.49–0.90），而 TAC 单倍型与抑郁症状显着正相关（粗略 OR 1.24；95% CI 1.01） –1.52）。这是第一项显示AGXT2 SNP rs180749、TGC 单倍型和 TAC 单倍型与抑郁症状之间存在显着关联的研究。