Abstract

Several dietary patterns and nutritional supplements have been linked to the development, progression, and symptomatic treatment of Parkinson’s disease (PD). Most of the evidence, at this point, is preliminary and based largely on observational studies. Interventional studies are scarce, so the evidence on effectiveness remains inconclusive. Dietary interventions could, analogous to exercise, potentially have a beneficial effect on disease symptoms as well as on the progression of the disease and should therefore be researched in high quality studies. Further work is also needed to study whether dietary interventions, when applied to an at-risk population, have any potential to postpone the onset of manifest PD. In this paper, we summarize all ongoing clinical trials on dietary interventions in PD. We found 10 ongoing studies, all aimed at a different intervention. These studies are mostly exploratory in nature or represent phase I or phase II trials focusing on safety, biological responses, and symptomatic effects. Taken together, we conclude that research on dietary interventions in persons with PD is still in its early days. The results of the various ongoing trials are expected to generate new hypotheses and will help to shape the agenda for future research on this important topic.

中文翻译：

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帕金森病的饮食干预

摘要

多种饮食模式和营养补充剂与帕金森病 (PD) 的发生、进展和对症治疗有关。目前，大多数证据都是初步的，并且主要基于观察性研究。干预性研究很少，因此有效性的证据仍不确定。与运动类似，饮食干预可能对疾病症状以及疾病进展产生有益影响，因此应该进行高质量的研究。还需要进一步的工作来研究饮食干预措施在应用于高危人群时是否有可能推迟明显的帕金森病的发作。在本文中，我们总结了所有正在进行的帕金森病饮食干预临床试验。我们发现了 10 项正在进行的研究，全部旨在不同的干预措施。这些研究大多是探索性的，或者代表 I 期或 II 期试验，重点关注安全性、生物反应和症状效应。综上所述，我们得出的结论是，对帕金森病患者的饮食干预研究仍处于早期阶段。正在进行的各种试验的结果预计将产生新的假设，并将有助于制定这一重要主题的未来研究议程。