The DNA damage response (DDR) is a complex and highly regulated cellular process that detects and repairs DNA damage. The integrity of the DNA molecule is crucial for the proper functioning and survival of cells, as DNA damage can lead to mutations, genomic instability, and various diseases, including cancer. The DDR safeguards the genome by coordinating a series of signaling events and repair mechanisms to maintain genomic stability and prevent the propagation of damaged DNA to daughter cells. The study of an ion channels in the context of DDR is a promising avenue in biomedical research. Lately, it has been reported that the movement of ions through channels plays a crucial role in various physiological processes, including nerve signaling, muscle contraction, cell signaling, and maintaining cell membrane potential. Knowledge regarding the involvement of ion channels in the DDR could support refinement of our approach to several pathologies, mainly cancer, and perhaps lead to innovative therapies. In this review, we focused on the ion channel's possible role in the DDR. We present an analysis of the involvement of ion channels in DDR, their role in DNA repair mechanisms, and cellular outcomes. By addressing these areas, we aim to provide a comprehensive perspective on ion channels in the DDR and potentially guide future research in this field. It is worth noting that the interplay between ion channels and the cellular DDR is complex and multifaceted. More research is needed to fully understand the underlying mechanisms and potential therapeutic implications of these interactions.

DNA 损伤反应 (DDR) 是一个复杂且高度调控的细胞过程，用于检测和修复 DNA 损伤。DNA 分子的完整性对于细胞的正常功能和生存至关重要，因为 DNA 损伤可能导致突变、基因组不稳定和各种疾病，包括癌症。DDR 通过协调一系列信号事件和修复机制来保护基因组，以维持基因组稳定性并防止受损 DNA 传播到子细胞。DDR 背景下离子通道的研究是生物医学研究中一个有前途的途径。最近，据报道，离子通过通道的运动在各种生理过程中发挥着至关重要的作用，包括神经信号传导、肌肉收缩、细胞信号传导和维持细胞膜电位。关于 DDR 中离子通道参与的知识可以支持改进我们针对多种病理学（主要是癌症）的方法，并可能带来创新疗法。在这篇综述中，我们重点关注离子通道在 DDR 中可能发挥的作用。我们对 DDR 中离子通道的参与、它们在 DNA 修复机制中的作用以及细胞结果进行了分析。通过解决这些领域，我们的目标是提供关于 DDR 中离子通道的全面视角，并有可能指导该领域的未来研究。值得注意的是，离子通道和细胞 DDR 之间的相互作用是复杂且多方面的。需要更多的研究来充分了解这些相互作用的潜在机制和潜在的治疗意义。