Alcohol dependence continues to be a major global burden despite significant research progress and treatment development. The aim of this study was to investigate whether neurofeedback training can alter resting state fMRI activity in brain regions that play a crucial role in addiction disorders in patients with alcohol dependence. For this purpose, a total of 52 patients were recruited for the present study, randomized, and divided into an active and a sham group. Patients in the active group received three sessions of neurofeedback training. We compared the resting state data in the active group as part of the NF training on six measurement days. When comparing the results of the active group from neurofeedback day 3 with baseline 1, a significant reduction in activated voxels in the ventral attention network area was seen. This suggests that reduced activity over the course of therapy in subjects may lead to greater independence from external stimuli. Overall, a global decrease in activated voxels within all three analysed networks compared to baseline was observed in the study. The use of resting-state data as potential biomarkers, as activity changes within these networks, may be to help restore cognitive processes and alcohol abuse-related craving and emotions.

尽管研究取得了重大进展并开发了治疗方法，但酒精依赖仍然是全球的主要负担。本研究的目的是调查神经反馈训练是否可以改变大脑区域的静息态功能磁共振成像活动，这些区域在酒精依赖患者的成瘾障碍中发挥着至关重要的作用。为此，本研究总共招募了 52 名患者，将其随机分为活性组和假组。活跃组的患者接受了三期神经反馈训练。作为 NF 训练的一部分，我们在六个测量日比较了活动组的静息状态数据。当将神经反馈第 3 天的活动组的结果与基线 1 进行比较时，发现腹侧注意网络区域的激活体素显着减少。这表明受试者在治疗过程中活动的减少可能会导致受试者更加独立于外部刺激。总体而言，与基线相比，研究中观察到所有三个分析网络中激活体素的整体减少。随着这些网络内活动的变化，使用静息态数据作为潜在的生物标志物可能有助于恢复认知过程和与酒精滥用相关的渴望和情绪。