Re-establishing tolerance to autoantigens is an important aim for the treatment of rheumatoid arthritis (RA). Immunization of HLA-DR4 transgenic mice with citrullinated self-antigens can induce immune tolerance, which suggests that such antigens could have a therapeutic role in anti-citrullinated peptide antibody-positive RA.

中文翻译：

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瓜氨酸肽的免疫耐受

重建对自身抗原的耐受性是治疗类风湿性关节炎（RA）的重要目标。用瓜氨酸自身抗原免疫HLA-DR4转基因小鼠可以诱导免疫耐受，这表明此类抗原可能对抗瓜氨酸肽抗体阳性的RA具有治疗作用。