Background Background Social isolation and loneliness pose significant public health challenges globally. The objective of this study is to investigate the association between social isolation, loneliness, and the risk of inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD). Methods Methods 275,157 UK adults from the UK Biobank (UKB) was analyzed. The exposures of interest were social isolation and loneliness. Social isolation was measured by the frequency of meeting family/friends, leisure and social activity, and communal/solitary living. Loneliness was evaluated by the subjective feeling of loneliness and the willingness to confide in others. The primary endpoint was incident IBD, including UC and CD. The twosample Mendelian randomization (MR) analysis was based on the genome-wide association studies of UKB and the a nonoverlapping European ancestry GWAS study. Results Results The UKB cohort study documented 1,565 IBD (1063 UC and 492 CD) cases during a mean follow-up of 13.49 years. Social isolation and loneliness showed significant associations with an elevated risk of IBD in UKB (social isolation [moderate vs least]: aHR 1.13, 95% CI 1.02-1.26; social isolation [most vs least]: aHR 1.31, 95% CI 1.01-1.70; loneliness [yes vs no]: aHR 1.29, 95% CI 1.04-1.60). These associations were evident among moderate genetic susceptibility to IBD. Social isolation and loneliness jointly increase the risk of IBD onset, with an aHR of 1.60 (95% CI 1.21-2.12). Two-sample MR analyses determined that engaging in fewer leisure/social activities (OR 3.42, 95% CI 1.55-7.58; 3.32, 95% CI 1.29-8.55; 3.09, 95% CI 1.35-7.07) were associated with increased IBD, UC and CD risk, whereas more activities-sports club or gym (OR 0.37, 95% CI 0.15-0.88) was associated with reduced IBD risk. Conclusion Conclusion Social isolation and loneliness are each associated with an elevated risk of IBD especially for individuals with a moderate genetic risk for IBD, with MR analyses suggesting potential causal links. The findings highlight the importance of promoting initiatives to address social isolation and loneliness as part of IBD prevention strategies.

中文翻译：

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P1123 社会隔离、孤独和炎症性肠病事件：大型前瞻性队列和孟德尔随机化的结果

背景 背景 社会孤立和孤独给全球带来了重大的公共卫生挑战。本研究的目的是调查社会孤立、孤独与炎症性肠病 (IBD)、溃疡性结肠炎 (UC) 和克罗恩病 (CD) 风险之间的关联。方法 方法 对来自英国生物银行 (UKB) 的 275,157 名英国成年人进行了分析。感兴趣的暴露是社会孤立和孤独。社会隔离是通过与家人/朋友见面的频率、休闲和社交活动以及公共/独居生活来衡量的。孤独感是通过主观的孤独感和向他人倾诉的意愿来评估的。主要终点是 IBD 事件，包括 UC 和 CD。双样本孟德尔随机化 (MR) 分析基于 UKB 的全基因组关联研究和非重叠欧洲血统 GWAS 研究。结果 UKB 队列研究在平均 13.49 年的随访期间记录了 1,565 例 IBD（1063 例 UC 和 492 例 CD）病例。社会隔离和孤独感与 UKB 的 IBD 风险升高显着相关（社会隔离[中度与最低]：aHR 1.13，95% CI 1.02-1.26；社会隔离[最高与最低]：aHR 1.31，95% CI 1.01- 1.70；孤独感[是与否]：aHR 1.29，95% CI 1.04-1.60）。这些关联在 IBD 的中度遗传易感性人群中很明显。社会孤立和孤独共同增加 IBD 发病风险，aHR 为 1.60（95% CI 1.21-2.12）。两个样本的 MR 分析确定，休闲/社交活动减少（OR 3.42，95% CI 1.55-7.58；3.32，95% CI 1.29-8.55；3.09，95% CI 1.35-7.07）与 IBD、UC 增加相关和 CD 风险，而更多的活动——体育俱乐部或健身房（OR 0.37，95% CI 0.15-0.88）与 IBD 风险降低相关。结论 结论 社会隔离和孤独感均与 IBD 风险升高相关，特别是对于具有中等 IBD 遗传风险的个体，MR 分析表明存在潜在的因果关系。研究结果强调了促进解决社会孤立和孤独感的举措作为 IBD 预防策略的一部分的重要性。