Abstract

Studying the proteome of helminths is of fundamental and applied importance, as it helps to find the molecular mechanisms underlying the life activity of parasitic organisms and the relationships in the parasite–host system. It also allows us to identify molecules that can be proposed as targets for creation of anthelmintic drugs. The review collects available information on the composition of proteins of parasitic worms. Based on data from genomic, transcriptomic and proteomic analysis of a small number of well-studied species, a primary description of the main groups of parasite proteins—structural proteins, carbohydrate metabolism enzymes, and proteins responsible for the body’s resistance to stress—was carried out. Comparative studies of the protein composition of some helminths at different stages of the life cycle are presented, and proteins typical for larvae and imago parasites are described. Works devoted to the study of proteins that parasites secrete into the external environment (secretomes) are discussed separately. It has been shown that the secretome proteins include various proteolytic enzymes, proteins of the detoxification system, signaling molecules, etc.

中文翻译：

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寄生蠕虫生命活动特征的蛋白质组学研究

摘要

研究蠕虫蛋白质组具有基础和应用重要性，因为它有助于发现寄生生物生命活动的分子机制以及寄生虫-宿主系统的关系。它还使我们能够识别可作为抗蠕虫药物的靶标的分子。该综述收集了有关寄生虫蛋白质组成的可用信息。基于对少数经过充分研究的物种的基因组、转录组和蛋白质组分析的数据，对寄生虫蛋白质的主要类别（结构蛋白质、碳水化合物代谢酶和负责身体抵抗压力的蛋白质）进行了初步描述。出去。对一些蠕虫在生命周期不同阶段的蛋白质组成进行了比较研究，并描述了幼虫和成虫寄生虫的典型蛋白质。致力于研究寄生虫分泌到外部环境中的蛋白质（分泌组）的著作将单独讨论。研究表明，分泌蛋白包括各种蛋白水解酶、解毒系统蛋白、信号分子等。