Reacting to the challenges presented by the evolving nexus of environmental change, defossilization, and diversified natural product bioprospecting is vitally important for advancing global healthcare and placing patient benefit as the most important consideration. This overview emphasizes the importance of natural and synthetic medicines security and proposes areas for global research action to enhance the quality, safety, and effectiveness of sustainable natural medicines. Following a discussion of some contemporary factors influencing natural products, a rethinking of the paradigms in natural products research is presented in the interwoven contexts of the Fourth and Fifth Industrial Revolutions and based on the optimization of the valuable assets of Earth. Following COP28, bioprospecting is necessary to seek new classes of bioactive metabolites and enzymes for chemoenzymatic synthesis. Focus is placed on those performance and practice modifications which, in a sustainable manner, establish the patient, and the maintenance of their prophylactic and treatment needs, as the priority. Forty initiatives for natural products in healthcare are offered for the patient and the practitioner promoting global action to address issues of sustainability, environmental change, defossilization, quality control, product consistency, and neglected diseases to assure that quality natural medicinal agents will be accessible for future generations.

Graphical Abstract

中文翻译：

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药品安全与生物勘探的当代联系：优先考虑患者的未来前景

应对不断变化的环境变化、去石化和多样化天然产物生物勘探所带来的挑战，对于推进全球医疗保健并将患者利益作为最重要的考虑因素至关重要。本概述强调了天然药物和合成药物安全的重要性，并提出了全球研究行动的领域，以提高可持续天然药物的质量、安全性和有效性。在讨论了影响天然产品的一些当代因素之后，在第四次和第五次工业革命的交织背景下，基于地球宝贵资产的优化，对天然产品研究范式进行了重新思考。在 COP28 之后，有必要进行生物勘探，以寻找新类别的生物活性代谢物和用于化学酶合成的酶。重点放在那些表现和实践的修改上，这些修改以可持续的方式将患者及其预防和治疗需求的维持作为优先事项。为患者和从业者提供了四十项医疗保健天然产品倡议，促进全球行动，解决可持续性、环境变化、去化石、质量控制、产品一致性和被忽视的疾病等问题，以确保未来可以获得优质的天然药物几代人。

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