Chromosomal instability (CIN) (a hallmark of human cancer) is caused by persistent errors in chromosome segregation during mitosis. Pharmacological inhibition of the mitotic kinesin KIF18A selectively exploits a mitotic vulnerability for which cancer models with CIN are enriched, which leads to robust anti-cancer effects and durable tumor regression in mice.

中文翻译：

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KIF18A 运动蛋白在染色体不稳定癌症中的治疗靶向

染色体不稳定 (CIN)（人类癌症的一个标志）是由有丝分裂过程中染色体分离的持续错误引起的。有丝分裂驱动蛋白 KIF18A 的药理抑制选择性地利用了有丝分裂的脆弱性，从而丰富了 CIN 癌症模型，从而在小鼠中产生强大的抗癌作用和持久的肿瘤消退。