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Mononuclear myeloid cells can shape neutrophils in brain tumors
Trends in Immunology ( IF 16.8 ) Pub Date : 2024-01-23 , DOI: 10.1016/j.it.2024.01.002
Sven Brandau

In most human solid cancer types, a high frequency of intratumoral neutrophils is associated with poor prognosis. In a recent study, Maas et al. identified an intratumoral niche in which mononuclear myeloid cells drive proinflammatory neutrophil activation in brain tumors. This study sheds new light on the intratumoral modulation of neutrophils.



中文翻译:

单核骨髓细胞可以塑造脑肿瘤中的中性粒细胞

在大多数人类实体癌类型中,肿瘤内中性粒细胞的高频率与不良预后相关。在最近的一项研究中,马斯等人。确定了一个瘤内生态位,其中单核骨髓细胞驱动脑肿瘤中的促炎性中性粒细胞激活。这项研究为中性粒细胞的瘤内调节提供了新的线索。

更新日期:2024-01-25
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