GRPR is a type of seven-transmembrane G-protein coupled receptor that belongs to the bombesin protein receptor family. It is highly expressed in various cancers, including prostate cancer, breast cancer, lung cancer, gastrointestinal cancer, and so on. As a result, molecular imaging studies have been conducted using radiolabeled GRPR ligands for tumor diagnosis, as well as monitoring of recurrence and metastasis. In this paper, we provided a comprehensive overview of relevant literature from the past two decades, with a specific focus on the advancements made in radiolabeled GRPR ligands for imaging prostate cancer and breast cancer.

中文翻译：

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放射性标记 GRPR 配体在癌症 PET/CT 成像中的进展

GRPR 是一种七跨膜 G 蛋白偶联受体，属于铃蟾肽蛋白受体家族。它在多种癌症中高表达，包括前列腺癌、乳腺癌、肺癌、胃肠道癌等。因此，人们使用放射性标记的 GRPR 配体进行分子成像研究，用于肿瘤诊断以及复发和转移的监测。在本文中，我们全面概述了过去二十年的相关文献，特别关注放射性标记 GRPR 配体在前列腺癌和乳腺癌成像方面取得的进展。