The intestinal microbiota, a complex ecosystem of microorganisms, has emerged as an important player in modulating various aspects of human health and disease. The microbiota is in a state of constant cross talk with itself and its host, and these interactions regulate several aspects of host homeostasis, including immune responses. Studies have demonstrated a relationship between the microbiota and outcomes of several cancer immunotherapies. This review explores the different roles of the microbiota in shaping the efficacy and safety of cancer immunotherapies, including allogeneic hematopoietic cell transplantation, immune checkpoint blockade, and CAR T cell therapy.Expected final online publication date for the Annual Review of Cancer Biology, Volume 8 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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肠道微生物群和免疫疗法的治疗反应

肠道微生物群是一个复杂的微生物生态系统，已成为调节人类健康和疾病各个方面的重要参与者。微生物群与其自身及其宿主处于不断交流的状态，这些相互作用调节宿主体内平衡的多个方面，包括免疫反应。研究证明了微生物群与几种癌症免疫疗法的结果之间的关系。本综述探讨了微生物群在影响癌症免疫疗法的功效和安全性方面的不同作用，包括同种异体造血细胞移植、免疫检查点阻断和 CAR T 细胞疗法。《癌症生物学年度评论》第 8 卷的预计最终在线出版日期是 2024 年 4 月。请参阅 http://www.annualreviews.org/page/journal/pubdates 了解修订后的估算。