Adenosine (Ado) drives immune suppression in the tumor microenvironment. In this issue of Cancer Cell, Klysz et al. investigate Ado-mediated immunosuppression. Overexpression of Ado deaminase (ADA-OE), metabolizing Ado to inosine (INO), induces stemness and improves CAR T cell functionality. Likewise, exposure to INO enhances CAR T cells’ function and induces stemness features.

中文翻译：

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释放 CAR T 细胞潜力：肌苷诱导的干细胞性和增强的效力

腺苷 (Ado) 驱动肿瘤微环境中的免疫抑制。在本期《癌细胞》中，Klysz 等人。研究 Ado 介导的免疫抑制。Ado 脱氨酶 (ADA-OE) 的过度表达，将 Ado 代谢为肌苷 (INO)，诱导干性并改善 CAR T 细胞功能。同样，暴露于 INO 可以增强 CAR T 细胞的功能并诱导干性特征。