Abstract

The intensity of the interaction between a helium cold atmospheric plasma jet (CAPJ) and a dielectric surface or animal skin is compared in experiment and numerical simulation. A cold plasma jet at atmospheric pressure is generated by a sinusoidal or positive pulsed voltage with different pulse durations in optimal modes. The impact effect is estimated on the basis of measured and calculated currents, line intensities in the CAPJ spectrum and temperature fields. The measured CAPJ characteristics show that the pulsed voltage for the CAPJ excitation is preferable compared to the sinusoidal mode. Varying the pulse duration of the periodic pulsed voltage makes it possible to obtain the maximum current and electric field strength at the surface within the permissible temperature in the contact area of the CAPJ with the skin of mice (<42°C). It is shown that the results of the CAPJ study obtained in physical experiments using a dielectric plate are applicable for tumor-bearing mice treatment.

中文翻译：

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正脉冲电压产生的冷大气等离子体射流在抗癌治疗中的优势

摘要

在实验和数值模拟中比较了氦冷大气等离子体射流（CAPJ）与介电表面或动物皮肤之间的相互作用强度。大气压下的冷等离子体射流由正弦或正脉冲电压产生，在最佳模式下具有不同的脉冲持续时间。根据测量和计算的电流、CAPJ 频谱中的线强度和温度场来估计冲击效应。测量的 CAPJ 特性表明，与正弦模式相比，CAPJ 激励的脉冲电压更佳。改变周期性脉冲电压的脉冲持续时间，可以在CAPJ与小鼠皮肤接触区域的允许温度（<42°C）内获得表面的最大电流和电场强度。结果表明，使用介电板的物理实验获得的CAPJ研究结果适用于荷瘤小鼠的治疗。