A protocol for the Chemoselective N-Boc protection of various types of amines has been developed. This includes heteroaryl, aliphatic, and alicyclic amines. The process makes use of malic acid as a catalyst and operates efficiently at ambient temperature without the need for solvents. This technique has been proven to effectively protect a wide range of functionalized amines containing both electron-donating and electron-withdrawing substituents. The benefits of this method include its fast reaction rate, high selectivity, excellent yield, catalyst recyclability, and environmentally friendly conditions.

中文翻译：

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苹果酸作为无溶剂条件下 N-Boc 保护的绿色催化剂

已开发出一种对各种类型的胺进行化学选择性 N-Boc 保护的方案。这包括杂芳基、脂肪族和脂环族胺。该工艺利用苹果酸作为催化剂，在环境温度下高效运行，无需溶剂。该技术已被证明可以有效保护多种含有给电子和吸电子取代基的官能化胺。该方法的优点包括反应速率快、选择性高、收率优异、催化剂可回收、环境友好。