Eukaryotic cells encounter diverse threats jeopardizing their integrity, prompting the development of defense mechanisms against these stressors. Among these mechanisms, inflammasomes are well-known for their roles in coordinating the inflammatory response against infections. Extensive research has unveiled their multifaceted involvement in cellular processes beyond inflammation. Recent studies emphasize the intricate relationship between the inflammasome and the DNA damage response (DDR). They highlight how the DDR participates in inflammasome activation and the reciprocal impact of inflammasome on DDR and genome integrity preservation. Moreover, novel functions of inflammasome sensors in DDR pathways have emerged, broadening our understanding of their roles. Finally, this review delves into identifying common signals that drive the activation of inflammasome sensors alongside activation cues for the DNA damage response, offering potential insights into shared regulatory pathways between these critical cellular processes.

中文翻译：

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炎症小体传感器与 DNA 损伤反应途径之间的串扰

真核细胞遇到多种威胁其完整性的威胁，从而促进针对这些压力源的防御机制的发展。在这些机制中，炎症小体因其在协调针对感染的炎症反应中的作用而闻名。广泛的研究揭示了它们在炎症以外的细胞过程中的多方面参与。最近的研究强调了炎症小体和 DNA 损伤反应 (DDR) 之间的复杂关系。他们强调了 DDR 如何参与炎症小体激活以及炎症小体对 DDR 和基因组完整性保存的相互影响。此外，DDR 通路中炎症小体传感器的新功能已经出现，拓宽了我们对其作用的理解。最后，本综述深入探讨了驱动炎症小体传感器激活的常见信号以及 DNA 损伤反应的激活线索，为这些关键细胞过程之间的共享调控途径提供了潜在的见解。