Breast cancer patients undergoing mastectomy receive silicone-implant-based breast reconstruction to mitigate the psychological distress of breast loss, typically in conjunction with adjuvant therapy. However, significant problems remain, such as systemic toxicity from chemotherapy and fibrosis that causes capsular contracture. Here, the development of a silicone implant coated with an alginate gel containing antisolvent-crystallized paclitaxel (acPTX) is reported. By antisolvent crystallization, the compact formulation of acPTX ensures slow release for long-term breast cancer recurrence prevention. The mixture of acPTX and the biodegradable alginate gel, which reduces fibrosis, is uniformly coated onto the silicone implant using 3D printed implant-specific molds based on the shape obtained from 3D scanning. In a breast cancer recurrence mouse model, silicone implants coated with acPTX gel show a long-term preventive effect compared to gel-coated implants with commercially available PTX. Furthermore, animal studies using C57BL/6 mice show that alginate-gel-coated implants significantly reduce capsule thickness, collagen density, and the number of fibrosis-related cells around the implant compared to silicone implants. The developed acPTX-gel-coated implant presents a promising approach for breast reconstruction in mastectomized breast cancer patients. It provides a novel platform for developing implants with long-term drug release properties.

中文翻译：

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含有抗溶剂结晶紫杉醇的藻酸盐涂层硅胶植入物可预防乳腺癌复发并减少纤维化

接受乳房切除术的乳腺癌患者接受基于硅胶植入物的乳房重建，以减轻乳房损失的心理困扰，通常与辅助治疗相结合。然而，重大问题仍然存在，例如化疗引起的全身毒性和导致包膜挛缩的纤维化。在此，报道了一种涂有含有抗溶剂结晶紫杉醇（acPTX）的藻酸盐凝胶的有机硅植入物的开发。通过反溶剂结晶，acPTX 的紧凑配方可确保缓慢释放，从而长期预防乳腺癌复发。根据 3D 扫描获得的形状，使用 3D 打印的植入物专用模具将 acPTX 和可减少纤维化的可生物降解藻酸盐凝胶的混合物均匀涂覆到硅胶植入物上。在乳腺癌复发小鼠模型中，与涂有市售 PTX 的凝胶涂层植入物相比，涂有 acPTX 凝胶的硅胶植入物显示出长期预防效果。此外，使用 C57BL/6 小鼠的动物研究表明，与硅胶植入物相比，藻酸盐凝胶涂层植入物显着降低了胶囊厚度、胶原蛋白密度以及植入物周围纤维化相关细胞的数量。开发的 acPTX 凝胶涂层植入物为乳房切除乳腺癌患者的乳房重建提供了一种有前景的方法。它为开发具有长期药物释放特性的植入物提供了一个新颖的平台。