High-throughput assay to simultaneously evaluate activation of CYP3A and the direct and time-dependent inhibition of CYP3A, CYP2C9, and CYP2D6 using liquid chromatography-tandem mass spectrometry,Xenobiotica

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High-throughput assay to simultaneously evaluate activation of CYP3A and the direct and time-dependent inhibition of CYP3A, CYP2C9, and CYP2D6 using liquid chromatography-tandem mass spectrometry
Xenobiotica ( IF 1.8 ) Pub Date : 2024-02-01 , DOI: 10.1080/00498254.2024.2308818
Yu Yumoto ₁ , Takuro Endo ₁ , Hiroshi Harada ₁ , Kaoru Kobayashi ₁ , Takeshi Nakabayashi ₁ , Yoshikazu Abe ₁

Affiliation

In the early stages of drug discovery, adequate evaluation of the potential drug–drug interactions (DDIs) of drug candidates is important. Several CYP3A activators are known to lead to underestimat...

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