A key distinguishing factor between mild cognitive impairment (MCI) and dementia in Parkinson’s disease (PD) lies in the notable decrease in functioning due to cognitive impairment. The Parkinson’s Disease-Cognitive Functional Rating Scale (PD-CRFS) was developed to assess functional limitations caused by cognitive impairment, while reducing the influence of motor impairment. The aim of this multicenter study was to (i) validate the Italian version of the PD-CFRS in PD, (ii) determine optimal cut-off scores for detecting MCI and dementia in PD, (iii) compare its performances with the most established functional assessment tool (IADL). Six hundred and sixty nine PD participants were recruited from 4 Italian Movement Disorders centers (Venice, Milan, Gravedona, and Salerno). They underwent Level-II cognitive evaluation, which resulted in 282 PD-NC, 310 PD-MCI, and 77 PDD. The PD-CFRS’s psychometric and clinimetric properties, applicability, and responsiveness were analyzed. The PD-CFRS showed high acceptability. Floor and ceiling effects were acceptable. It also displayed strong internal consistency (Cronbach’s α = 0.738), and test–retest reliability (ICC = .854). The PD-CFRS demonstrated higher coefficient of variation to detect dysfunction in PD-MCI patients in comparison to the IADL scale (PD-CFRS 96% vs IADL 22.5%). Convergent validity with the IADL was r = − 0.638 and − 0.527 in males and females, respectively. PD-CFRS total score negatively correlated with global cognition (MoCA corrected score r = − 0.61; p < 0.001). A cut-off score > 6.5 identified PDD with a sensitivity of 90% and specificity of 88% (AUC = .959). A cut-off value of > 1 detected PD-MCI with a sensitivity of 68% and specificity of 69% (AUC = .695). The Italian version of the PD-CFRS demonstrated to be an easy, valid and reliable tool that properly captures functional impairment due to cognitive decline in PD. It also proved to be particularly effective in the advanced stages of PD, and would be a useful support for the diagnosis of PD-MCI and PDD.

轻度认知障碍（MCI）和帕金森病（PD）痴呆之间的一个关键区别因素在于认知障碍导致的功能显着下降。帕金森病认知功能评定量表（PD-CRFS）旨在评估认知障碍引起的功能限制，同时减少运动障碍的影响。这项多中心研究的目的是 (i) 验证意大利版本的 PD-CFRS 在 PD 中的应用，(ii) 确定检测 PD 中 MCI 和痴呆的最佳截止分数，(iii) 将其性能与最成熟的 PD-CFRS 进行比较功能评估工具（IADL）。从 4 个意大利运动障碍中心（威尼斯、米兰、格拉维多纳和萨勒诺）招募了 669 名 PD 参与者。他们接受了 II 级认知评估，结果为 282 名 PD-NC、310 名 PD-MCI 和 77 名 PDD。分析了 PD-CFRS 的心理测量和临床测量特性、适用性和响应性。PD-CFRS 显示出较高的可接受性。地板和天花板的效果是可以接受的。它还显示出很强的内部一致性（Cronbach's α = 0.738）和重测可靠性（ICC = .854）。与 IADL 量表相比，PD-CFRS 在检测 PD-MCI 患者功能障碍方面表现出更高的变异系数（PD-CFRS 96% vs IADL 22.5%）。男性和女性中 IADL 的收敛效度分别为 r = − 0.638 和 − 0.527。PD-CFRS 总分与整体认知负相关（MoCA 校正得分 r = − 0.61；p < 0.001）。截止分数 > 6.5 确定 PDD 的敏感性为 90%，特异性为 88% (AUC = .959)。检测 PD-MCI 的截止值 > 1，灵敏度为 68%，特异性为 69% (AUC = .695)。意大利版本的 PD-CFRS 被证明是一种简单、有效和可靠的工具，可以正确捕获由于 PD 认知下降而导致的功能障碍。它还被证明对 PD 晚期特别有效，并将为 PD-MCI 和 PDD 的诊断提供有用的支持。