Over time, chiral organometallic compounds have attracted great interest in several fields, with applications going across several disciplines of chemical, biological, medical, and material sciences. In the last decades, due to advancements in molecular design and computational modeling, the chemistry of chiral transition metal complexes had a remarkable flowering, with the development of new structures for applications in asymmetric synthesis, bioinorganic chemistry, and molecular recognition. In these fields, fast chiral analysis to determine the enantiomeric purity of organometallic structures prepared by asymmetric synthesis, and for high-throughput screening of analytes, catalysts, and reactions, is very important. Capillary electrophoresis and related techniques proved to be extremely versatile for chiral analysis, showing unsurpassed advantages compared to chromatography like low consumption of materials, production of limited amounts of waste, fast equilibration, and possibility to replace easily type and concentration of the chiral selector, among others. Furthermore, electromigration techniques may be useful to gain details about the stereochemistry of the enantiomers of new compounds and to study analyte–selector noncovalent interactions at molecular level. On this basis, this short review aims to provide the reader with a comprehensive view on the enantioseparation of organometallic compounds by electromigration techniques, examining the topic from the historical perspective and showing what was made in this field so far, an essential know-how for developing new and advanced applications in the next future.

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通过电迁移技术对有机金属化合物进行对映体分离

随着时间的推移，手性有机金属化合物引起了多个领域的极大兴趣，其应用遍及化学、生物、医学和材料科学等多个学科。在过去的几十年中，由于分子设计和计算模型的进步，手性过渡金属配合物的化学取得了显着的发展，并开发了用于不对称合成、生物无机化学和分子识别应用的新结构。在这些领域中，快速手性分析以确定不对称合成制备的有机金属结构的对映体纯度，以及分析物、催化剂和反应的高通量筛选非常重要。毛细管电泳和相关技术被证明在手性分析中用途广泛，与色谱法相比显示出无与伦比的优势，例如材料消耗低、废物产生量有限、快速平衡以及可以轻松更换手性选择器的类型和浓度等。其他的。此外，电迁移技术可能有助于获得新化合物对映体立体化学的详细信息，并研究分子水平上的分析物-选择器非共价相互作用。在此基础上，这篇简短的综述旨在为读者提供关于通过电迁移技术进行有机金属化合物对映分离的全面看法，从历史的角度审视该主题，并展示迄今为止在该领域取得的成果，这是电迁移技术的基本知识。在未来开发新的和先进的应用程序。