Objective

Our objective is to innovatively integrate both linear and nonlinear characteristics of brain signals in Electroconvulsive Therapy (ECT) research, with the goal of uncovering deeper insights into the pathogenesis of Major Depressive Disorder (MDD) and identifying novel targets for other physical intervention therapies.

Methods

We measured brain entropy (BEN) in 42 MDD patients and 42 matched healthy controls (HC) using rs-fMRI data. Brain regions that differed significantly in patients with MDD before and after ECT were extracted. Then, we use these brain regions as seed points to investigate the differences in whole-brain resting-state functional connectivity (RSFC) patterns before and after ECT.

Results

Compared to HCs, patients had higher BEN levels in the right precuneus (PCUN.R) and right angular gyrus (ANG.R). After ECT, patients had lower BEN levels in the PCUN.R and ANG.R. Compared with before ECT, patients showed significantly increased RSFC after ECT between the PCUN.R and right middle temporal gyrus and ANG.R. Significantly increased RSFC was observed between the ANG.R and right middle frontal gyrus and right supramarginal gyrus after ECT.

Conclusion

Combining the linear and nonlinear characteristics of brain signals can effectively explore the pathogenesis of depression and provide new targets for ECT.

中文翻译：

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电休克治疗重度抑郁症引起的大脑熵和功能连接模式的改变

客观的

我们的目标是在电休克治疗 (ECT) 研究中创新性地整合脑信号的线性和非线性特征，旨在更深入地了解重度抑郁症 (MDD) 的发病机制，并确定其他物理干预疗法的新靶点。

方法

我们使用 rs-fMRI 数据测量了 42 名 MDD 患者和 42 名匹配的健康对照 (HC) 的脑熵 (BEN)。提取 ECT 前后 MDD 患者显着差异的大脑区域。然后，我们使用这些大脑区域作为种子点来研究 ECT 前后全脑静息态功能连接 (RSFC) 模式的差异。

结果

与 HC 相比，患者右侧楔前叶 (PCUN.R) 和右角回 (ANG.R) 的 BEN 水平较高。ECT 后，患者 PCUN.R 和 ANG.R 中的 BEN 水平较低。与 ECT 之前相比，ECT 后患者 PCUN.R 和右颞中回以及 ANG.R 之间的 RSFC 显着增加。ECT 后观察到 ANG.R 与右侧额中回和右侧边缘上回之间的 RSFC 显着增加。

结论

结合脑信号的线性和非线性特征，可以有效探索抑郁症的发病机制，为ECT提供新的靶点。