The rapid corrosion rate and limited biological functionality still pose challenges for magnesium (Mg)-based implants in the treatment of complicated bone-related diseases in clinic. Herein, a multifunctional biodegradable curcumin (herbal medicine)-ferrum (Cur-Fe) nanoflower was self-assembled on plasma electrolytic oxidation (PEO)-treated Mg alloy via a facile immersion process to realize differential biological function for anti-bacteria/tumor and bone regeneration. The results indicated that Cur-Fe nanoflower coating can promote protein adsorption, cell adhesion and proliferation, exhibiting excellent biocompatibility. The Cur-Fe nanoflower coating exhibits unique degradation characteristics, as curcumin gradually decomposes into ferulic acid, aromatic aldehyde and other antibacterial substances, and the coating spontaneously converts into FeOOH nanosheets, ensuring the corrosion resistance of Mg-based implants. Moreover, Cur-Fe coating exhibits remarkable narrow gap semiconductor characteristics, which can generate reactive oxygen species (ROS) and demonstrated excellent antibacterial effect under simulated sunlight (SSL) irradiation. Meanwhile, under NIR irradiation, Cur-Fe coating showed excellent chemotherapy/photodynamic/photothermal synergetic antitumor properties in vitro and in vivo due to the introduction of curcumin, and photocatalysis and photothermal conversion properties of coating. Furthermore, Cur-Fe nanoflower coating demonstrated great osteogenesis activity in vitro and in vivo due to unique micro/nano structure, surface chemical bond, and the release of Mg and Fe ions.

快速的腐蚀速率和有限的生物功能仍然对临床上复杂的骨相关疾病的镁基植入物的治疗提出了挑战。在此，通过简单的浸泡过程在等离子体电解氧化（PEO）处理的镁合金上自组装多功能可生物降解姜黄素（草药）-铁（Cur-Fe）纳米花，以实现抗菌/肿瘤和抗肿瘤的差异生物功能。骨再生。结果表明，Cur-Fe纳米花涂层能够促进蛋白质吸附、细胞粘附和增殖，表现出优异的生物相容性。Cur-Fe纳米花涂层表现出独特的降解特性，姜黄素逐渐分解为阿魏酸、芳香醛等抗菌物质，涂层自发转化为FeOOH纳米片，保证了镁基植入物的耐腐蚀性。此外，Cur-Fe涂层表现出显着的窄带隙半导体特性，可以产生活性氧（ROS），并在模拟太阳光（SSL）照射下表现出优异的抗菌效果。同时，在近红外辐射下，由于姜黄素的引入，Cur-Fe涂层在体外和体内表现出优异的化疗/光动力/光热协同抗肿瘤性能，以及涂层的光催化和光热转换性能。此外，由于独特的微/纳米结构、表面化学键以及镁和铁离子的释放， Cur-Fe纳米花涂层在体外和体内表现出良好的成骨活性。