Cultural and generational trends have increasingly favored “anti-inflammatory” action, innovating a new class of analgesic, non-steroidal anti-inflammatory drugs (NSAIDs) in the 20th century. The modern human body has been molded over evolutionary time and while acknowledging inflammation can be pathologically entwined, it also serves an important role in healthy folliculogenesis and ovulation, shaping cues that drive needed vascular change. This review argues that because of anti-inflammatory action, the cultural invention of NSAIDs represents a particular stressor on female reproductive-age bodies, interacting with natural, underlying variation and placing limits on healthy growth and development in the follicles, creating potential autism risk through hypoxia and mutagenic or epigenetic effects. Since testes are analogs to ovaries, the biological grounding extends naturally to spermatogenesis. This review suggests the introduction of over-the-counter NSAIDs in the 1980s failed to recognize the unique functioning of reproductive-age bodies, challenging the cyclical inflammation needed for healthy gamete development. NSAIDs are framed as one (notable) stressor in an anti-inflammatory era focused on taming the risks of inflammation in modern human life.

中文翻译：

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缺氧、非甾体抗炎药和自闭症：配子发生过程中压力源的生物文化分析

文化和世代趋势越来越青睐“抗炎”作用，在 20 世纪创新了一类新型镇痛非甾体抗炎药 (NSAID)。现代人体是在进化过程中形成的，虽然承认炎症可能在病理上相互交织，但它在健康的卵泡发生和排卵中也发挥着重要作用，形成驱动所需血管变化的线索。这篇综述认为，由于非甾体抗炎药的抗炎作用，文化发明的非甾体抗炎药对女性育龄身体产生了特殊的压力，与自然的、潜在的变异相互作用，限制了卵泡的健康生长和发育，通过以下方式创造了潜在的自闭症风险：缺氧和诱变或表观遗传效应。由于睾丸类似于卵巢，因此生物基础自然延伸到精子发生。这篇综述表明，20 世纪 80 年代引入非处方非甾体抗炎药未能认识到育龄身体的独特功能，从而挑战了健康配子发育所需的周期性炎症。非甾体抗炎药被认为是抗炎时代的一种（值得注意的）压力源，其重点是控制现代人类生活中的炎症风险。