Endovascular coiling is the predominant method for treating cerebral aneurysms. Extensive reports on selecting coil length, hardness, and material are available. However, the impact of coil diameter on postoperative outcomes remains unclear. This study enrolled six personalized geometric models of intracranial aneurysms: three bifurcation aneurysms and three sidewall aneurysms. Four coil models were constructed by changing the coil diameter. Coil embolization was simulated using the finite element method. Computational fluid dynamics was used to characterize hemodynamics in the aneurysms after embolization. Evaluation parameters included velocity reduction, wall shear stress (WSS), low WSS (LWSS), oscillatory shear index (OSI), relative residence time (RRT), and residual flow volume in the aneurysms. At the peak time (t = 0.17 s), the proportion of LWSS area in bifurcation aneurysms increase with the rise in coil diameter: 0.8D, 71.28 ± 12.62% versus 1D, 74.97 ± 19.17% versus 1.2D, 78.88 ± 18.56% versus 1.4D, 84.00 ± 11.53% (mean ± SD). The proportion of high OSI area decreases as the coil diameter increases: 0.8D, 4.41% ± 2.82% versus 1.0D, 3.78 ± 3.33% versus 1.2D, 2.28% ± 1.77% versus 1.4D, 1.58% ± 1.11% (mean ± SD). The proportion of high RRT area increases as the coil diameter rises: 0.8D, 3.40% ± 1.68% versus 1.0D, 7.67 ± 4.12% versus 1.2D, 9.84% ± 9.50% versus 1.4D, 22.29% ± 14.28% (mean ± SD). Side wall aneurysms do not exhibit the aforementioned trend. Bifurcation aneurysms plugged with a coil of 1.4 times the diameter have the largest RFVs (<10 mm/s) within the group. Aforementioned patterns are not found in sidewall aneurysms. In the treatment of aneurysms with coiling, varying coil diameters can result in different hemodynamic environments within the aneurysm. Larger coil diameters have improved hemodynamic performance for bifurcation aneurysms. However, coil diameter and embolization effectiveness have no significant relationship for sidewall aneurysms.

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不同直径栓塞弹簧圈治疗颅内动脉瘤的血流动力学研究

血管内弹簧圈栓塞是治疗脑动脉瘤的主要方法。我们提供有关选择线圈长度、硬度和材料的大量报告。然而，弹簧圈直径对术后结果的影响仍不清楚。这项研究纳入了六种个性化的颅内动脉瘤几何模型：三个分叉动脉瘤和三个侧壁动脉瘤。通过改变线圈直径构建了四个线圈模型。使用有限元法模拟弹簧圈栓塞。计算流体动力学用于表征栓塞后动脉瘤的血流动力学。评估参数包括速度降低、壁剪切应力 (WSS)、低 WSS (LWSS)、振荡剪切指数 (OSI)、相对停留时间 (RRT) 和动脉瘤中的残余流量。在峰值时间（t  = 0.17 s），分叉动脉瘤中 LWSS 面积的比例随着弹簧圈直径的增加而增加：0.8D、71.28 ± 12.62% vs 1D、74.97 ± 19.17% vs 1.2D、78.88 ± 18.56% vs 1D 1.4D，84.00 ± 11.53%（平均值 ± 标准差）。高 OSI 区域的比例随着线圈直径的增加而减少：0.8D、4.41% ± 2.82% 与 1.0D、3.78 ± 3.33% 与 1.2D、2.28% ± 1.77% 与 1.4D、1.58% ± 1.11%（平均值 ±标准差）。高 RRT 区域的比例随着线圈直径的增加而增加：0.8D，3.40% ± 1.68% 对比 1.0D，7.67 ± 4.12% 对比 1.2D，9.84% ± 9.50% 对比 1.4D，22.29% ± 14.28%（平均值 ±标准差）。侧壁动脉瘤不表现出上述趋势。用 1.4 倍直径的线圈塞住的分叉动脉瘤具有组内最大的 RFV (<10 mm/s)。在侧壁动脉瘤中未发现上述模式。在用弹簧圈治疗动脉瘤时，不同的弹簧圈直径会导致动脉瘤内产生不同的血流动力学环境。较大的线圈直径改善了分叉动脉瘤的血流动力学性能。然而，线圈直径和栓塞效果对于侧壁动脉瘤没有显着关系。