: Cancer stem cells (CSCs) have become a key player in the growth of tumors, the spread of cancer, and the resistance to therapeutic interventions. Targeting these elusive cell populations has the potential to fundamentally alter cancer treatment plans. CSCs, also known as tumor-initiating cells (TICs), are thought to play a role in both medication resistance and cancer recurrence. This is explained by their capacity to regenerate themselves and change into different kinds of cancer cells. Due to their higher expression of ATP-binding cassette (ABC) membrane transporters, enhanced epithelial to mesenchymal (EMT) characteristics, improved immune evasion, activation of survival signaling pathways, and improved DNA repair mechanisms, CSCs exhibit extraordinary resistance to therapies. This comprehensive analysis delves into advancements in the domain of Targeted Cancer Stem Cell Therapeutics, concentrating on unraveling the distinctive traits of CSCs and the therapeutic methods devised to eliminate them.

中文翻译：

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靶向癌症干细胞治疗：最新进展

：癌症干细胞 (CSC) 已成为肿瘤生长、癌症扩散和治疗干预耐药性的关键参与者。针对这些难以捉摸的细胞群有可能从根本上改变癌症治疗计划。 CSC，也称为肿瘤起始细胞 (TIC)，被认为在耐药性和癌症复发中发挥着重要作用。这是因为它们具有自我再生和转变为不同种类癌细胞的能力。由于 ATP 结合盒 (ABC) 膜转运蛋白的较高表达、增强的上皮间质 (EMT) 特性、改善的免疫逃避、激活生存信号通路以及改善的 DNA 修复机制，CSC 表现出非凡的治疗抵抗力。这项综合分析深入研究了靶向癌症干细胞治疗领域的进展，重点揭示了 CSC 的独特特征以及旨在消除它们的治疗方法。