The ribonucleic acid (RNA)-binding protein Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1), a key member of the CPEB family, is essential in controlling gene expression involved in both healthy physiological and pathological processes. CPEB1 can bind to the 3'- untranslated regions (UTR) of substrate messenger ribonucleic acid (mRNA) and regulate its translation. There is increasing evidence that CPEB1 is closely related to the pathological basis of atherosclerosis. According to recent investigations, many pathological processes, including inflammation, lipid metabolism, endothelial dysfunction, angiogenesis, oxidative stress, cellular senescence, apoptosis, and insulin resistance, are regulated by CPEB1. This review considers the prevention and treatment of atherosclerotic heart disease in relation to the evolution of the physiological function of CPEB1, recent research breakthroughs, and the potential participation of CPEB1 in atherosclerosis.

中文翻译：

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细胞质多腺苷酸化元件结合蛋白1与动脉粥样硬化：前瞻性目标和新见解

核糖核酸 (RNA) 结合蛋白细胞质多腺苷酸化元件结合蛋白 1 (CPEB1) 是 CPEB 家族的关键成员，对于控制健康生理和病理过程中涉及的基因表达至关重要。 CPEB1 可以结合底物信使核糖核酸 (mRNA) 的 3'-非翻译区 (UTR) 并调节其翻译。越来越多的证据表明CPEB1与动脉粥样硬化的病理基础密切相关。根据最近的研究，许多病理过程，包括炎症、脂质代谢、内皮功能障碍、血管生成、氧化应激、细胞衰老、细胞凋亡和胰岛素抵抗等，都受到CPEB1的调节。本综述探讨了动脉粥样硬化性心脏病的预防和治疗与CPEB1生理功能进化的关系、最新研究突破以及CPEB1在动脉粥样硬化中的潜在参与。