: Ferroptosis is a newly discovered form of programmed cell death characterized by iron overload, ROS accumulation, and lipid peroxidation. It is distinguished by unique morphological, biochemical, and genetic features and stands apart from other known regulated cell death mechanisms. Studies have demonstrated a close association between ferroptosis and various cancers, including liver cancer, lung cancer, renal cell carcinoma, colorectal cancer, pancreatic cancer, and ovarian cancer. Inducing ferroptosis has shown promising results in inhibiting tumor growth and reversing tumor progression. However, the challenge lies in regulating ferroptosis in vivo due to the scarcity of potent compounds that can activate it. Integrating emerging biomedical discoveries and technological innovations with conventional therapies is imperative. Notably, considerable progress has been made in cancer treatment by leveraging immunotherapy and nanotechnology to trigger ferroptosis. This review explores the relationship between ferroptosis and emerging immunotherapies and nanotechnologies, along with their potential underlying mechanisms, offering valuable insights for developing novel cancer treatment strategies.

中文翻译：

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针对癌症铁死亡的新兴治疗方法：关注免疫疗法和纳米技术

：铁死亡是一种新发现的程序性细胞死亡形式，其特征是铁超载、ROS 积累和脂质过氧化。它具有独特的形态、生化和遗传特征，有别于其他已知的受调节细胞死亡机制。研究表明铁死亡与多种癌症之间存在密切关系，包括肝癌、肺癌、肾细胞癌、结直肠癌、胰腺癌和卵巢癌。诱导铁死亡在抑制肿瘤生长和逆转肿瘤进展方面显示出有希望的结果。然而，由于缺乏可以激活铁死亡的有效化合物，挑战在于调节体内铁死亡。将新兴生物医学发现和技术创新与传统疗法相结合势在必行。值得注意的是，通过利用免疫疗法和纳米技术引发铁死亡，在癌症治疗方面取得了相当大的进展。这篇综述探讨了铁死亡与新兴免疫疗法和纳米技术之间的关系，以及它们潜在的潜在机制，为开发新型癌症治疗策略提供了宝贵的见解。