Inhibiting glutamine metabolism has thus far been clinically challenging. Two studies in preclinical mouse models now report that, in contrast to the failure of glutaminase inhibitors, broad suppression of glutamine metabolism with glutamine analogs delivered to tumors results in reduced pancreatic cancer growth, with targetable resistance mechanisms.

中文翻译：

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用于胰腺癌治疗的谷氨酰胺类似物

迄今为止，抑制谷氨酰胺代谢在临床上一直具有挑战性。目前，两项临床前小鼠模型研究报告称，与谷氨酰胺酶抑制剂的失败相反，通过向肿瘤递送谷氨酰胺类似物广泛抑制谷氨酰胺代谢，可减少胰腺癌的生长，并具有可靶向的耐药机制。