Heat-based local ablation techniques are effective treatments for specific oligometastatic and localized cancers and are being studied for their potential to induce immunogenic cell death and augment systemic immune responses to immunotherapies. The diverse technologies associated with thermal therapy have an unmet need for method development to enable device-specific experimentation, optimization, calibration and refinement of the parameter space to optimize therapeutic intent while minimizing side effects or risk to the patient. Quality assurance, training, or comparing thermal dose among different modalities or techniques using animal models is time and resource intensive. Therefore, the application and use of tissue mimicking thermosensitive, thermochromic liquid crystal and thermochromic paint phantom models may reduce costs and hurdles associated with animal use. Further, their homogenous composition may enable more precise assessment of ablative techniques. This review utilized SciFinder, Web of Science, PubMed and EMBASE to systematically evaluate the literature describing the background and applications of thermochromic liquid crystal, thermochromic paint and tissue-mimicking thermochromic phantoms used to characterize the thermal effects of ablation devices with a focus on facilitating their use across the medical device development life cycle.

中文翻译：

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用于表征和建模图像引导热烧蚀和烧蚀装置的热致变色模型和涂料：综述

基于热的局部消融技术是针对特定寡转移和局部癌症的有效治疗方法，并且正在研究其诱导免疫原性细胞死亡和增强对免疫疗法的全身免疫反应的潜力。与热疗法相关的多种技术对方法开发的需求尚未得到满足，以实现设备特定的实验、优化、校准和参数空间的细化，以优化治疗目的，同时最大限度地减少对患者的副作用或风险。使用动物模型进行质量保证、培训或比较不同方式或技术之间的热剂量需要大量时间和资源。因此，模仿组织的热敏、热致变色液晶和热致变色涂料模型模型的应用和使用可以降低与动物使用相关的成本和障碍。此外，它们的均质成分可以使消融技术的评估更加精确。本综述利用 SciFinder、Web of Science、PubMed 和 EMBASE 系统地评估了描述热致变色液晶、热致变色涂料和模拟组织热致变色模型的背景和应用的文献，这些模型用于表征消融装置的热效应，重点是促进它们的应用。在整个医疗设备开发生命周期中使用。