Microplastics pose significant challenges to ecosystems and organisms. They can be ingested by marine and terrestrial species, leading to potential health risks and ecological disruptions. This study aims to address the urgent need for effective remediation strategies by focusing on the biodegradation of microplastics, specifically polyvinyl chloride (PVC) derivatives, using the bacterial strain Bacillus albus. The study provides a comprehensive background on the accumulation of noxious substances in the environment and the importance of harnessing biodegradation as an eco-friendly method for pollutant elimination. The specific objective is to investigate the enzymatic capabilities of Bacillus albus, particularly the alpha/beta hydrolases (ABH), in degrading microplastics. To achieve this, in-silico studies were conducted, including analysis of the ABH protein sequence and its interaction with potential inhibitors targeting PVC derivatives. Docking scores of − 7.2 kcal/mol were obtained to evaluate the efficacy of the interactions. The study demonstrates the promising bioremediation prospects of Bacillus albus for microplastics, highlighting its potential as a key player in addressing microplastic pollution. The findings underscore the urgent need for further experimental validation and practical implementation of Bacillus albus in environmental remediation strategies.

微塑料给生态系统和生物体带来了重大挑战。它们可能被海洋和陆地物种摄入，导致潜在的健康风险和生态破坏。本研究旨在通过使用白色芽孢杆菌菌株重点关注微塑料（特别是聚氯乙烯 (PVC) 衍生物）的生物降解，解决对有效修复策略的迫切需求。该研究为环境中有毒物质的积累以及利用生物降解作为消除污染物的环保方法的重要性提供了全面的背景。具体目标是研究白色芽孢杆菌，特别是 α/β 水解酶 (ABH) 降解微塑料的酶能力。为了实现这一目标，我们进行了计算机模拟研究，包括分析 ABH 蛋白序列及其与针对 PVC 衍生物的潜在抑制剂的相互作用。获得- 7.2 kcal/mol 的对接分数来评估相互作用的功效。该研究展示了白色芽孢杆菌对微塑料的生物修复前景，凸显了其作为解决微塑料污染的关键参与者的潜力。研究结果强调了在环境修复策略中进一步实验验证和实际实施白色芽孢杆菌的迫切需要。