Family history of hypertension is associated with early autonomic dysfunction and increased oxidative stress. These alterations have been found to be reinforced by the overweight factor. Conversely, an active lifestyle is effective in improving the mechanisms regulating blood pressure control. Hence, we ought to investigate the effects of an active lifestyle on the hemodynamic, autonomic and oxidative stress parameters in individuals carrying both family history of hypertension and overweight risk factors. Fifty-six normotensive males were divided into four groups: eutrophic offspring of normotensive parents (EN, n = 12), eutrophic and inactive with hypertensive parents (EH, n = 14), overweight and inactive with hypertensive parents (OH, n = 13), and overweight and physically active with hypertensive parents (OAH, n = 17). Cardiovascular autonomic modulation was assessed by heart rate (HRV) and blood pressure (BPV) variability indexes. Oxidative stress included pro/antioxidant markers and nitrite concentration. Inactive offspring of hypertensive parents (EH and OH) showed higher LF_SBP (vs EN), an indicator of sympathetic outflow to the vasculature and reduced anti-oxidant activity (vs EN), while higher pro-oxidant markers were found exclusively in OH (vs EN and EH). Conversely, the OAH group showed bradycardia, higher vagally-mediated HF_abs index (vs OH and EN), lower sympathovagal balance (vs OH) and preserved LF_SBP. Yet, the OAH showed preserved pro/antioxidant markers and nitrite levels. Our findings indicates that overweight offspring of hypertensive parents with an active lifestyle have improved hemodynamic, cardiac autonomic modulation and oxidative stress parameters compared to their inactive peers.

高血压家族史与早期自主神经功能障碍和氧化应激增加有关。人们发现，超重因素会强化这些改变。相反，积极的生活方式可以有效改善血压控制的调节机制。因此，我们应该研究积极的生活方式对具有高血压家族史和超重危险因素的个体的血流动力学、自主神经和氧化应激参数的影响。56 名血压正常的男性被分为四组：血压正常的父母的富营养化后代（EN，n  = 12）、高血压父母的富营养化且不活动（EH，n  = 14）、高血压父母的超重且不活动（OH，n  = 13） ），以及患有高血压的父母超重且经常运动（OAH，n  = 17）。通过心率（HRV）和血压（BPV）变异指数评估心血管自主调节。氧化应激包括促氧化/抗氧化标记物和亚硝酸盐浓度。高血压父母（EH 和 OH）不活跃的后代表现出较高的 LF _SBP（与EN 相比），这是交感神经流出脉管系统的指标，并且抗氧化活性降低（与EN 相比），而较高的促氧化标记物仅在 OH 中发现（对比EN 和 EH）。相反，OAH 组表现出心动过缓、迷走_神经介导的 HF 绝对指数较高（相对于OH 和 EN）、较低的交感迷走神经平衡（相对于OH）和保留的 LF _SBP。然而，OAH 显示出保留的促氧化/抗氧化标记物和亚硝酸盐水平。我们的研究结果表明，与不活跃的同龄人相比，生活方式活跃的高血压父母的超重后代的血流动力学、心脏自主调节和氧化应激参数有所改善。