Objective To report neurodevelopment at age 5.5 years according to developmental delay screening with the Ages & Stages Questionnaire (ASQ) in late infancy in preterm-born children. Design Population-based cohort study, EPIPAGE-2. Setting France, 2011–2017. Participants 2504 children born at 24–26, 27–31 and 32–34 weeks, free of cerebral palsy, deafness or blindness at 2 years’ corrected age. Main outcome measures Moderate/severe, mild or no disability at age 5.5 years using gross and fine motor, sensory, cognitive and behavioural evaluations. Results of the ASQ completed between 22 and 26 months’ corrected age described as positive screening or not. Results Among 2504 participants, 38.3% had ASQ positive screening. The probability of having moderate/severe or mild disability was higher for children with ASQ positive versus negative screening: 14.2% vs 7.0%, adjusted OR 2.5 (95% CI 1.8 to 3.4), and 37.6% vs 29.7%, adjusted OR 1.5 (1.2 to 1.9). For children with ASQ positive screening, the probability of having neurodevelopmental disabilities at age 5.5 years was associated with the number of domain scores below threshold, very low gestational age and severe neonatal morbidities. For children with ASQ negative screening, this probability was increased for boys and children born small-for-gestational age. For both groups, maternal level of education was strongly associated with outcomes. Conclusion In preterm-born children, ASQ screening at 2 years’ corrected age was associated with neurodevelopmental disabilities at age 5.5 years. However, other factors should be considered when interpreting the ASQ data to draw further follow-up. Trial registration number 2016-A00333-48. Data are available upon reasonable request. Data are available upon reasonable request and will be shared in accordance with the European regulation.

中文翻译：

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根据早产儿 2 岁校正年龄的年龄和阶段问卷调查，5.5 岁时的神经发育：EPIPAGE-2 队列研究

目的 根据年龄和阶段问卷 (ASQ) 的发育迟缓筛查，报告早产儿 5.5 岁时的神经发育情况。设计基于人群的队列研究，EPIPAGE-2。设定法国，2011-2017。参与者 2504 名出生于 24-26 周、27-31 周和 32-34 周的儿童，在 2 岁校正年龄时没有脑瘫、耳聋或失明。主要结果通过粗大和精细运动、感觉、认知和行为评估来衡量 5.5 岁时的中度/重度、轻度或无残疾。 ASQ 结果在校正年龄 22 至 26 个月之间完成，描述为阳性筛查或非阳性筛查。结果 在 2504 名参与者中，38.3% 的 ASQ 筛查呈阳性。 ASQ 筛查呈阳性的儿童与阴性筛查的儿童相比，出现中度/重度或轻度残疾的概率更高：14.2% vs 7.0%，调整后 OR 2.5（95% CI 1.8 至 3.4），以及 37.6% vs 29.7%，调整后 OR 1.5（ 1.2 至 1.9）。对于 ASQ 筛查呈阳性的儿童，5.5 岁时出现神经发育障碍的概率与低于阈值的领域分数数量、极低胎龄和严重的新生儿发病率相关。对于 ASQ 筛查阴性的儿童，男孩和小于胎龄儿的这种概率会增加。对于两组来说，母亲的教育水平与结果密切相关。结论 在早产儿中，2 岁时的 ASQ 筛查与 5.5 岁时的神经发育障碍相关。然而，在解释 ASQ 数据以进行进一步跟进时，应考虑其他因素。试用注册号2016-A00333-48。数据可根据合理要求提供。数据可根据合理要求提供，并将根据欧洲法规进行共享。